Hi, need to submit a 2000 words essay on the topic Structure of The Major Histocompatibiltiy Complex (MHC).
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The functions performed by the complex are: binding of peptide fragments from invading pathogens and then displaying these peptide fragments on the cell surface so that it should be recognized by T-cells fro further degradation.
MHC has got two unique properties, which make it difficult for any pathogen to evade immune responses in this way. These are:i) the MHC is polygenic: there are different varieties of MHC class I and MHC class II genes, hence every individual has got a set of MHC molecules with different ranges of peptide-binding specificities.ii) the MHC is highly polymorphic. there are multiple variants of each gene within the population as a whole. The MHC genes are, in fact, the most polymorphic genes known (Janeway 2001).