I will pay for the following essay Asbestos Increases Mammalian AP- Endonuclease Gene Expression, Protein Levels, and Enzyme Activity in Mesothelial Cells. The essay is to be 2 pages with three to five sources, with in-text citations and a reference page.
Most previous studies have focused on DNA repair in bacteria. Asbestos has been found to increase the production of 8-hydroxydeoxyguanosine (8OHdG), a modified DNA nucleoside. Conversion to 8OHdG has been attributed to oxidative stress. Inheritance of damaged DNA can result in permanent mutation, leading to disease, and cell proliferation. 8OHdG can be removed by DNA base excision repair enzyme systems in mammals and through the action of AP endonuclease (APE), which acts similarly to E. coli exonuclease III and endonuclease IV. AP endonuclease excises the modified base on a segment of the DNA strand. The lacking base is then replaced through the action of other members of the DNA repair system, restoring the original, correct sequence of the DNA.