Microsoft Word – CBMS223-assignment
Other plasma proteins have been studied for their ability to bind to glycosaminoglycans. One such protein is kininogen, which is a lysine-rich protein. Like HPRG, kininogen is able to bind to glycosaminoglycans, but this binding is far less sensitive to small fluctuations in physiological pH.
Q11. Why does kininogen bind to glycosaminoglycans easily? Q12. Why is the binding of kininogen less sensitive to physiological pH changes?