the normal pH of blood ranges anywhere between ≈ 7.35 and 7.45.The heart generated 169 mmHg at a pH of 7.4. And 42 mmHg at a pH of 6.8.Enzymes are a biological catalyst, nearly always a protein, speeding up a reaction without changing its products or reactants. When there is a significant change in pH, the protein undergoes a process called “denaturing” in which, the shape of the protein changes which then affects its ability to function properly or function at all. Because 7.4 is within the normal pH range for blood, the heart was able to carry out its normal function as it should and generate far more pressure than when the pH level was at 6.8. On the other hand, due to the low pH level change of 6.8, the protein within the blood changes, making it difficult for the heart to function with it, thus decreasing the amount of pressure generated – which would typically be the cause of myocardial ischemia.
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PH and Cardiac FunctionSummary : As a pump , the function of the heart is to fill with blood and contract , thus generating pressure to promotethe flow of blood to tissues of the body . It has been widely reported that decreasing intracellular PH , which may occurduring myocardial ischemia , impairs the ability of the heart to generate pressure by altering protein structure andfunction . Given , however , that most of these investigations have utilized skinned muscle preparations , we chose insteadto use a Langendorff isolated heart preparation ( Figure 1 ) to explore these effects at the level of the heart . Methods : 12hearts were obtained from anesthetized rats , placed on a Langendorff perfusion apparatus and perfused with a modifiedKHB solution ( similar in composition to blood ) . Left ventricular pressure was recorded using a pressure transducer*following 10 – 15 minutes of equilibration under 2 conditions : PH1 7 . 4 and PH1 6 .8 . A summary of the results obtained fromthis investigation is found in Figure 2 .200180160141Left VentricularDeveloped Pressure ( mmile). . . ( The19 8 8 8 9 90Figure 1 : Langendorff Perfusion Apparatus7. 46.8PHFigure 2: LV Developed Pressure at a PH of 7 . 4 and 6 .8
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